A sense of satisfaction and well-being that covers various aspects of life can be defined as quality of life (QoL). Hypothyroidism can be clinically both latent and apparent. It is possible to evaluate general aspects of life, identify the presence and severity of diseases, and evaluate the effectiveness of treatment while QoL measurement instruments are used. The timely initiation of levothyroxine (LT4) substitution in cases with latent hypothyroidism and the evaluation of LT4 substitution quality serve as evidence of the beneficial effects of used QoL instruments. Here, we introduced GHQ12, TSQ, and ThyPRO instruments most commonly used in routine thyroid clinical practice.